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KMID : 0545120020120050834
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Journal of Microbiology and Biotechnology
2002 Volume.12 No. 5 p.834 ~ p.837
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Effect of 2-NBDG, a Fluorescent Derivative of Glucose, on Microbial Cell Growth
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Shin Dong-Sun
OH KI-BONG
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Abstract
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A fluorescent glucose analogue, 2-[N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)amino]-2-deoxy-D-glucose(2-NBDG), which had previously been developed for the analysis of glucose uptake in living cells, was investigates to determine its biological activity on microorganisms. 2-NBDG did not show any inhibitory effect on growth of yeast cells and bacteria. In contrast, 2-NDBG exhibited strong inhibitory effects on filamentous fungal growth. The growth of filamentous fungi was completely inhibited, when 2-NBDG was supplemented as sole carbon source. The inhibitory effect was decreased by the addition of glucose in the test medium. Furthermore, 2-NBDG inhibited chitinase activity of Trichoderma sp. These results suggested that the inhibitory effects of 2-NBDG on filamentous fungi might be partially due to the inhibition of chitinase.
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